Pair Name	Fucoxanthin, TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2C77]	Cervical cancer		Investigative
Gene Regulation	Down-regulation	Phosphorylation	AKT1	hsa207
	Down-regulation	Phosphorylation	PIK3CA	hsa5290
In Vitro Model	Ca Ski	Human papillomavirus-related cervical squamous cell carcinoma	Homo sapiens (Human)	CVCL_1100
In Vivo Model	Five-week-old nude BALB/c mice were used for subcutaneous implantation of human cervical tumor cells HeLa (2×10⁶ per site).
Result	The findings of this study suggest that the combined use of fucoxanthin and TRAIL might be a useful strategy against TRAIL-resistant cervical cancer.

Pair Name	Fucoxanthin, TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2C77]	Cervical cancer		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Down-regulation	Phosphorylation	AKT1	hsa207
	Up-regulation	Expression	BAX	hsa581
	Down-regulation	Expression	BCL2	hsa596
	Up-regulation	Cleavage	CASP3	hsa836
	Down-regulation	Expression	RELA	hsa5970
In Vitro Model	HeLa	Human papillomavirus-related cervical adenocarcinoma	Homo sapiens (Human)	CVCL_0030
	SiHa	Human papillomavirus-related cervical squamous cell carcinoma	Homo sapiens (Human)	CVCL_0032
	Ca Ski	Human papillomavirus-related cervical squamous cell carcinoma	Homo sapiens (Human)	CVCL_1100
Result	We found that fucoxanthin- or TRAIL-induced apoptosis of human cervical cancer cells was obviously down-regulated. CONCLUSIONS Taken together, these findings suggest that fucoxanthin and TRAIL increased the apoptosis in human cervical cancer cells by targeting the PI3K/Akt/NF-κB signaling pathway.